Polynucleotides for Under-Eye Rejuvenation London
Whether you opt for polynucleotide treatments, tear trough fillers, salmon sperm injections, or the innovative Lumi Eyes, each approach offers unique benefits for under-eye rejuvenation and overall skin rejuvenation.

What is Polynucleotides?
Polynucleotide (PN) injections offer an innovative solution for under-eye rejuvenation, providing a natural and regenerative alternative to traditional fillers. Composed of nucleotides—the fundamental units of DNA and RNA—polynucleotides work by stimulating the body’s natural repair mechanisms.
When used in skin boosters and facial rejuvenation treatments, they promote collagen and elastin production, improving skin elasticity, hydration, and texture.
This helps reduce fine lines, wrinkles, and dark circles under the eyes. Unlike conventional fillers that add volume, PN injections revitalize the skin from within, delivering long-lasting, natural-looking results.

Our Under-Eye Rejuventation Treatments
At The Harley Skin Clinics, we offer cutting-edge acne treatments designed to effectively target breakouts, reduce inflammation, and promote long-term skin health. Using state-of-the-art technology and scientifically proven methods, our treatments cater to both active acne and acne scarring.

Lumi Eyes (Polynucleotides)
Lumi Eyes is a cutting-edge tissue stimulator specifically formulated for the delicate under-eye area and tear trough. This advanced treatment provides a subtle filling effect without the risk of lymphoedema, offering a safe and effective solution for under-eye concerns.
Key Benefits of Lumi Eyes:
- Reduction of Dark Circles
- Decreased Puffiness
- Minimization of Fine Lines & Wrinkles
- Enhanced Skin Texture & Tone
Recommended Treatment Plan:
For optimal results, a series of two treatments spaced four weeks apart is advised. The procedure can be repeated biannually to maintain long-lasting rejuvenation.

Nucleofill (Polynucleotides)
Nucleofill is a groundbreaking innovation in aesthetic medicine, offering a comprehensive injectable treatment for skin rejuvenation, anti-aging, and under-eye revitalization. This advanced biotechnology harnesses the power of polynucleotides to stimulate the skin’s natural regenerative processes through a three-fold mechanism:
- Fibroblast Activation & Collagen Production
- Deep Hydration & Antioxidant Protection
Who is this Treatment for?
Nucleofill is ideal for individuals experiencing a decline in skin elasticity, radiance, and hydration, regardless of age or skin type. This natural, hypoallergenic treatment is formulated as a transparent gel, ensuring both safety and efficacy in restoring a vibrant, youthful complexion.

Tear Trough Fillers
Tear trough fillers are a highly effective solution for reducing under-eye hollows, dark circles, and puffiness. Composed primarily of hyaluronic acid, these fillers restore lost volume and enhance hydration in the delicate tear trough area.
Upon injection, they deliver immediate results by smoothing hollows and brightening dark circles, creating a refreshed and youthful appearance.
Aftercare Information:
While results are long-lasting, maintenance treatments every 6 to 12 months are recommended to sustain optimal effects. Proper aftercare and choosing an experienced practitioner are essential to achieving natural, balanced results.
Book A Free 30 Minute Consultation Today!
Polynucleotides Prices
At The Harley Skin Clinics, we offer competitive pricing for our Under-Eye Rejuvenation treatments.
Lumi Eyes
£149.00
*Choosing the right treatment depends on your specific needs, desired results, and skin type
**Prices are subject to change without prior notice. Please contact us for the latest pricing and promotions.
Nucleofill (Face)
£199.00
*Choosing the right treatment depends on your specific needs, desired results, and skin type
**Prices are subject to change without prior notice. Please contact us for the latest pricing and promotions.
Frequently Asked Questions
Polynucleotide injections are regenerative skin treatments that use DNA-derived molecules to stimulate collagen and elastin production. They enhance skin hydration, improve elasticity, and reduce fine lines, dark circles, and wrinkles by promoting the body’s natural healing processes.
Lumi Eyes is a tissue stimulator designed specifically for the under-eye area. Unlike traditional fillers that add volume, Lumi Eyes works by improving skin quality, hydration, and texture without the risk of lymphoedema. It stimulates collagen production, reducing dark circles, puffiness, and fine lines while maintaining a natural look.
Nucleofill is an advanced polynucleotide-based injectable designed to enhance skin quality and elasticity. It works by stimulating fibroblast activity, boosting collagen and elastin production, deeply hydrating the skin, and providing antioxidant protection. It’s particularly beneficial for individuals experiencing skin laxity, dullness, or dehydration.
Tear trough fillers are hyaluronic acid-based injectables used to restore volume, smooth hollows, and brighten dark circles under the eyes. They are ideal for individuals experiencing tired-looking eyes due to aging, genetics, or volume loss.
- Polynucleotide injections (including Nucleofill & Lumi Eyes): Results last around 6–12 months, with maintenance treatments recommended twice a year.
- Tear Trough Fillers: Typically last 6–12 months, depending on individual metabolism and lifestyle factors.
- Lumi Eyes & Nucleofill: A minimum of two sessions, spaced four weeks apart, is recommended, with maintenance every 6–12 months.
- Tear Trough Fillers: Usually, one session provides immediate results, but touch-ups may be needed over time.
Most treatments have minimal downtime. Some mild swelling, redness, or bruising may occur, but these effects usually subside within a few days. Patients can typically return to daily activities immediately after treatment.
Yes, all treatments mentioned—Polynucleotide injections, Lumi Eyes, Nucleofill, and Tear Trough Fillers—are clinically tested and considered safe when administered by a qualified professional. They are biocompatible, with a low risk of allergic reactions.
Yes, Polynucleotide injections (such as Lumi Eyes and Nucleofill) can be combined with tear trough fillers for enhanced under-eye rejuvenation. Polynucleotides improve skin quality, hydration, and elasticity, while fillers restore lost volume, providing a comprehensive anti-aging effect.
These treatments may not be suitable for individuals who:
- Are pregnant or breastfeeding.
- ave active skin infections or inflammatory skin conditions.
- Have a history of severe allergies to any of the injectable components.
- Have certain medical conditions affecting wound healing or collagen production.
For best results, a consultation with a qualified practitioner is recommended to determine the most suitable treatment plan based on individual skin concerns.
How To Book
We make booking your treatment quick and easy. Choose from one of the three convenient options below:
Online
Booking online is the fastest way to secure your appointment. Select a suitable date and time, and confirm your booking instantly.
Phone
Give us a call to ask any questions, get expert advice on the best treatment for your needs, and book your appointment over the phone.
For a quick way to book, message us on WhatsApp. Our team will respond promptly to help you schedule an appointment or answer any questions.
Visit Our Clinic
If you’d like to book in person or need directions to our clinic, we’re easy to find. Our London laser clinic is centrally located with excellent transport links.
Our Opening Hours
Our hours of operations as follows below:
- Monday – Thursday 11:00-20:30
- Friday- Saturday 09:00-18:30
- Sunday Closed
*Closed all public/bank holidays
Need More Information?
We offer free consultations to help you choose the right treatment. Our clinic provides flexible appointment times, including evenings and weekends, to fit your schedule. All treatments are performed by qualified professionals using safe and effective laser technology.
Still have questions? Contact us, and we’ll be happy to help!